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JNCI Journal of the National Cancer Institute 2005 97(4):251-253; doi:10.1093/jnci/97.4.251
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© 2005 Oxford University Press

NEWS

Feeding the Flame: New Research Adds to Role of Inflammation in Cancer Development

Vicki Brower

The first 150 words of the full text of this article appear below.

When Rudolf Virchow observed in 1863 that tumors—whose English name comes from the Latin "tumere," to swell—harbor leukocytes, he saw a connection between inflammation and cancer. Since the early 20th century, scientists have come to understand that hepatitis B and C, Epstein-Barr virus, and infectious agents such as Helicobacter pylori initiate long-term local tissue inflammation that can result in cancer.

A protective mechanism by which an organism responds to infection, injury, or tissue damage, inflammation had been considered a secondary reaction to cancer. But a growing body of research that examines the tumor microenvironment is providing information on the molecular mechanisms behind inflammation's role in initiating and/or promoting a wide range of cancers, with new implications for prevention, monitoring, and treatment.

A recent study published in November in Science by JeanMarie Houghton, Ph.D., of the University of Massachusetts School of Medicine, and Timothy Wang, M.D., of Columbia University College . . . [Full Text of this Article]

‘Wounds That Do Not Heal’

Cytokines and Chemokines

NF-{kappa}B


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