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JNCI Journal of the National Cancer Institute 2005 97(4):245-246; doi:10.1093/jnci/dji059
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© 2005 Oxford University Press

EDITORIAL

Preventing Infection-Associated Cancer: From Bench to Hillside

James J. Goedert

Correspondence to: James J. Goedert, MD, Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Rm. 8012, Rockville, MD 20892 (e-mail: goedertj@mail.nih.gov).

The first 10% of the full text of this article appears below.

Identifying, characterizing, and interrupting the primary cause of a disease is far more effective than diagnosing and treating the disease itself. As the saying goes, "An ounce of prevention is worth a pound of cure." Together, laboratory and epidemiologic research efforts have identified several viruses and one bacterium as human carcinogens. Research on hepatitis B virus (HBV) and its association with hepatocellular carcinoma (HCC) exemplifies the historical accomplishments, current progress, and challenges remaining for cancer prevention once the cause is known.

In 1965, Blumberg et al. (1) reported the initial detection of the "Australia antigen," which was found in serum from an Australian aborigine and is now known as hepatitis B virus surface antigen (HBsAg). During the 1970s, chronic carriage of HBsAg was closely tied to HBV infection during infancy . . . [Full Text of this Article]


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