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JNCI Journal of the National Cancer Institute 2005 97(24):1798-1799; doi:10.1093/jnci/dji450
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© 2005 Oxford University Press

EDITORIAL

New and Surprising Insights Into Pathogenesis of Multicentric Squamous Cancers in the Female Lower Genital Tract

Qinghua Feng, Nancy B. Kiviat

Affiliation of authors: Department of Pathology, University of Washington, Seattle

Correspondence to: Nancy B. Kiviat, MD, Department of Pathology, Box 358050, University of Washington, 815 Mercer St., Seattle, WA 98109 (e-mail: nbk@u.washington.edu).

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Infection with high-risk types of human papillomavirus (HR-HPV) is extremely common in the cervix, vagina, and vulva; and women with persistent HR-HPV infections at these sites have been shown to be at increased risk for the development of invasive squamous cell cancers at these locations (1–3). Prior to the establishment of routine cervical cancer screening, invasive cervical cancer was among the most common causes of cancer mortality in women. Compared with cervical cancer, vaginal and vulvar cancers develop infrequently (current age-adjusted incidences of cervical, vaginal, and vulvar cancers = 8.9/100 000 women per year, 0.7/100 000 women per year, and 2.3/100 000 women per year, respectively) (4). Previous studies (e.g., [5,6]. . . [Full Text of this Article]


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