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JNCI Journal of the National Cancer Institute 2005 97(23):1714-1715; doi:10.1093/jnci/dji437
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© 2005 Oxford University Press

EDITORIAL

Blockade of the TGF-{beta} Superfamily by Smad7: Breaking a Link in the Metastatic Chain

Isaiah J. Fidler

Correspondence to: Isaiah J. Fidler, DVM, PhD, M. D. Anderson Cancer Center, Department of Cancer Biology, Unit 173, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: ifidler@mdanderson.org).

The first 10% of the full text of this article appears below.

The major cause of death from cancer is metastases that are resistant to conventional therapies (1). The pathogenesis of metastasis is dynamic and complex and consists of a series of many interrelated steps. To produce a clinically relevant lesion, metastatic cells must complete all of the following steps: 1) After the initial transformation event, continuous proliferation of tumor cells takes place. 2) This progressive growth of neoplasms requires vascularization. The synthesis and secretion of several angiogenic factors by some tumor cells play key roles in this process. The genetic instability of neoplastic cells in general and metastatic cells in particular leads to the generation . . . [Full Text of this Article]


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Home page
 Acta Biochim Biophys SinHome page
X. Yan, Z. Liu, and Y. Chen
Regulation of TGF-{beta} signaling by Smad7
Acta Biochim Biophys Sin, April 1, 2009; 41(4): 263 - 272.
[Abstract] [Full Text] [PDF]