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JNCI Journal of the National Cancer Institute 2005 97(22):1634-1635; doi:10.1093/jnci/dji414
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© 2005 Oxford University Press

EDITORIAL

Deguelin as a Chemopreventive Agent in Mouse Lung Tumorigenesis Induced by Tobacco Smoke Carcinogens

Stephen S. Hecht

Correspondence to: Stephen S. Hecht, PhD, The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St. SE, Minneapolis, MN 55455 (e-mail: hecht002@umn.edu).

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In this issue of the Journal, Lee et al. (1) present interesting data on deguelin, a potential chemopreventive agent against lung tumorigenesis. This compound, isolated from several plant species, is already known to inhibit the P13K–Akt pathway, to decrease expression of cyclooxygenase 2, and to induce apoptosis in premalignant and malignant human bronchial epithelial cells, with minimal effects on normal human bronchial epithelial cells. These are all potentially favorable properties with respect to chemoprevention. The study reported here demonstrates, in mouse models, that deguelin decreases expression of pAkt in lung and inhibits lung tumorigenesis induced by the tobacco smoke carcinogens benzo[a]pyrene (BaP) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), administered in combination. The effects were particularly striking considering the relatively low dose of deguelin, 4 mg/kg . . . [Full Text of this Article]


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