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JNCI Journal of the National Cancer Institute 2005 97(20):1486-1487; doi:10.1093/jnci/dji359
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© 2005 Oxford University Press

EDITORIAL

A Piece of the Melanoma Puzzle

Alisa M. Goldstein, Margaret A. Tucker

Affiliation of authors: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD

Correspondence to: Alisa M. Goldstein, PhD, Genetic Epidemiology Branch/NCI/NIH/DHHS, Executive Plaza South, Rm. 7004, 6120 Executive Blvd. MSC 7236, Bethesda, MD 20892–7236 (e-mail: goldstea@exchange.nih.gov).

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Cutaneous malignant melanoma (CMM) is a complex disorder with genetic, environmental, and host factors contributing to its pathogenesis. CDKN2A is the major known high-risk melanoma susceptibility gene. MC1R also influences melanoma risk but is described as a low-risk susceptibility gene (1–3). Although much has been learned since CDKN2A was identified, much remains to be discovered. The article by Begg et al. (4) in this issue of the Journal provides another piece of the intricate puzzle.

Begg et al. (4) estimated the lifetime risk of melanoma among relatives of CDKN2A mutation carriers who were ascertained using a population-based study design. Probands were incident CMM . . . [Full Text of this Article]


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