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© 2005 Oxford University Press
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Which Came First? Studies Clarify Role of Aneuploidy in Cancer
| The first 150 words of the full text of this article appear below. |
Almost from the moment cytologists first noticed that cancer cells contain an abnormal number of chromosomes, researchers have debated the significance of the observation. It's a classic "chicken/egg" dilemma, and one that has aroused passions on both sides of the issue. Does chromosomal instability cause cancer, or is the condition of aneuploidy merely a consequence of predisposing gene mutations? A flurry of recent research is beginning to clarify the issue and in many cases is placing aneuploidy in the front and center of the carcinogenic process.
Within the past few months, several research teams have shown direct links
between cancer syndromes and abnormalities in the surveillance system that
ensures accurate chromosome segregation during cell division. Nazeen Rahman,
Ph.D., of the Institute of Cancer Research in Sutton, England, and her
colleagues reported in the November 2004 issue of Nature Genetics
that inherited mutations in a key protein involved in ensuring accurate
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  B. A.A. Weaver and D. W. Cleveland Aneuploidy: Instigator and Inhibitor of Tumorigenesis Cancer Res., November 1, 2007; 67(21): 10103 - 10105. [Abstract] [Full Text] [PDF]
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