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JNCI Journal of the National Cancer Institute 2005 97(2):84-85; doi:10.1093/jnci/dji038
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© 2005 Oxford University Press

EDITORIAL

Measuring DNA Repair Capacity: Small Steps

Marianne Berwick, Paolo Vineis

Affiliations of authors: Division of Epidemiology, University of New Mexico, Albuquerque, NM (MB); University of Torino, Imperical College, London, UK (PV)

Correspondence to: Marianne Berwick, PhD, MPH, Division of Epidemiology, Epidemiology and Cancer Prevention, MSC 08 4630, CRF 103A, University of New Mexico, Albuquerque, NM 87131–0001 (e-mail: mberwick@salud.unm.edu)

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DNA repair capacity is a system of defenses designed to protect the integrity of the genome. The difficulty in studying DNA repair capacity in relationship to cancer etiology stems from the costs inherent in conducting whole cell assays, which represent an integrated response to DNA damage, and from the lack of specificity of the current genetic assays, which generally focus on the role of single nucleotide polymorphisms. Studies of DNA repair capacity and cancer etiology require careful consideration of design, potential bias and confounding, and, importantly, assessment of assay variability, both intra-individual and inter-individual, as well as biologic plausibility (. . . [Full Text of this Article]


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