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JNCI Journal of the National Cancer Institute 2005 97(16):1175-1177; doi:10.1093/jnci/dji269
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© 2005 Oxford University Press

NEWS

Researchers Attempting To Define Role of Cytokines in Cancer Risk

Vicki Brower

The first 150 words of the full text of this article appear below.

Earlier this year, a team of researchers from Austria found in a case–control study that women who produced more of the cytokine interleukin 10 (IL-10) due to a genetic variation or polymorphism had a lower incidence of breast cancer.

"The mechanism remains to be determined but may include antiangiogenic functions of IL-10," said study leader Uwe Langsenlehner, M.D., of the Medical University of Graz, Austria. "If this result can be confirmed in additional studies, determination of IL-10 genotypes may help give a more precise individual breast cancer risk profile." This research, published in March in Breast Cancer Research and Treatment, is one of a growing number of studies that are helping to define how cytokine polymorphisms affect cancer risk, initiation, and progression.

IL-10 is one of more than 300–400 known cytokines produced by the immune system that are mediators of immunity, infection, and inflammation, said Joost Oppenheim, M.D., chief . . . [Full Text of this Article]

Cytokines in the Microenvironment

Pathogen Connection?


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