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JNCI Journal of the National Cancer Institute 2005 97(16):1170-1171; doi:10.1093/jnci/dji246
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© 2005 Oxford University Press

EDITORIAL

Should Screen-detected Breast Cancers Be Managed Differently?

Monika K. Krzyzanowska, Ian F. Tannock

Affiliation of authors: Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Canada

Correspondence to: Ian F. Tannock MD, PhD, Division of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave., Toronto, ON M45G 2M9, Canada (e-mail: ian.tannock@uhn.on.ca).

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In this issue of the Journal, Shen et al. (1) examine the prognostic value of the method of breast cancer detection on cancer-specific survival. They used data from three large North American randomized controlled trials of breast cancer screening to evaluate the prognosis of screen-detected cancers versus cancers in interval and control groups. Across all three trials, screen-detected tumors were associated with longer cancer-specific survival, although the benefit was attenuated after adjustment for known prognostic factors such as stage, tumor size, and axillary lymph node status. This article complements the findings of Joensuu et al. (2), which were based on the Finnish Cancer Registry and which also reported better survival for women with screen-detected tumors, after adjusting for a range of known prognostic factors. Should . . . [Full Text of this Article]


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