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JNCI Journal of the National Cancer Institute 2005 97(15):1114-1115; doi:10.1093/jnci/dji260
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© 2005 Oxford University Press

NEWS

Studies Define Role of microRNA in Cancer

Karyn Hede

The first 10% of the full text of this article appears below.

Once ignored completely or overlooked as cellular detritus, short snippets of RNA discovered only a little over a decade ago are turning out to be crucial regulators of cell growth, differentiation, and death.

These small 20- to 23-nucleotide noncoding sequences, dubbed microRNA (miRNA), help regulate protein production in the cell by binding to a complementary site in protein-coding messenger RNA (mRNA), effectively preventing it from being translated, and, in some cases, targeting it for destruction.

It now appears that at least some of the more than 200 miRNA sequences discovered in the human genome contribute to the development of cancer. Three papers published simultaneously in the June 9 issue of Nature demonstrate that miRNAs are not only part of the process that leads to cancer but in some cases may act as oncogenes . . . [Full Text of this Article]


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