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JNCI Journal of the National Cancer Institute 2005 97(15):1107-1109; doi:10.1093/jnci/dji244
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© 2005 Oxford University Press

EDITORIAL

Fecal DNA Biomarkers for the Detection of Colorectal Neoplasia: Attractive, but Is It Feasible?

Dean E. Brenner, Gad Rennert

Affiliations of authors: Departments of Internal Medicine and Pharmacology, University of Michigan Medical Center, Ann Arbor (DEB); VA Medical Center, Ann Arbor, MI (DEB); Clalit Health Service National Israeli Cancer Control Center, Haifa (GR); Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel (GR)

Correspondence to: Dean E. Brenner, MD, 2150 CCGC, University of Michigan Cancer Center, Ann Arbor, MI 48109-0930 (e-mail: dbrenner@umich.edu).

The first 150 words of the full text of this article appear below.

Because of the high mortality associated with advanced disease, accessibility to direct visual examination, extensive research, and recognition of the genetic mechanisms associated with its carcinogenesis, the colon and rectum have emerged as an important model for the introduction of innovative and effective cancer screening and early detection tools for large populations.

Detection of Colorectal Neoplasia: Need for Improved Methods

Wide-scale screening using fecal occult blood testing (FOBT) results in 15%–33% reduction in colorectal adenocarcinoma mortality, but at the expense of many unneeded colonoscopies (1–6). Despite specificity of approximately 95% and reasonable cost-effectiveness, FOBT's test sensitivity ranges from 15% to 30% (7), leaving room for substantial improvement. Traditionally low FOBT sensitivities, reflecting standard office practice (8,9), may be improved when employed in an organized, structured program (10,11). The addition of sigmoidoscopy to FOBT increases the detection of adenomas by approximately . . . [Full Text of this Article]

Fecal Based DNA Tests for the Detection of Colorectal Neoplasia

Improving Upon Current Fecal DNA Diagnostic Tools


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