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JNCI Journal of the National Cancer Institute 2005 97(14):1089-1090; doi:10.1093/jnci/dji119
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© 2005 Oxford University Press

CORRESPONDENCE

Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia

Roberto L. Vargas, Raymond E. Felgar, Paul G. Rothberg

Affiliation of authors: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY

Correspondence to: Paul G. Rothberg, PhD, Department of Pathology and Laboratory Medicine, 601 Elmwood Ave., Box 626, Rochester, NY 14642 (e-mail: Paul_Rothberg@urmc.rochester.edu).

The first 10% of the full text of this article appears below.

We read with interest the report of Moshynska et al. (1) on the discovery of two different insertional mutations at the same position in the promoter of the MCL-1 gene in chronic lymphocytic leukemia (CLL) specimens. The insertions, of 6 or 18 nucleotides, were associated with increased expression of MCL-1 mRNA and protein and with a poorer prognosis for the patients. In preparation for the development of a rapid and focused . . . [Full Text of this Article]


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Response to this Correspondence

RESPONSE: Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia
Oksana Moshynska and Anurag Saxena
J Natl Cancer Inst 2005 97: 1093-1095. [Extract] [Full Text] [PDF]