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JNCI Journal of the National Cancer Institute 2005 97(14):1088-1089; doi:10.1093/jnci/dji118
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© 2005 Oxford University Press

CORRESPONDENCE

Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia

Scott N. Freeman, Gerold Bepler, Eric Haura, Rebecca Sutphen, W. Douglas Cress

Affiliations of authors: Molecular Oncology Program (SNF, WDC), Thoracic Oncology Program (GB, EH), and Cancer Control Program (RS), The H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL

Correspondence to: Doug Cress, PhD, Molecular Oncology Program, The H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612-9497 (e-mail: cressd@moffitt.usf.edu).

The first 10% of the full text of this article appears below.

A recent article entitled "Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia" identified two novel sequence variants of the MCL-1 promoter within lymphocytes from chronic lymphocytic leukemia (CLL) patients but not within noncancerous tissue from the same individuals or in lymphocytes from 18 healthy control subjects (1). This result suggested that the variants—insertions of 6 and 18 nucleotides at position –188 relative to the transcription start site as mapped by Akgul et al. (2)—were CLL-related somatic oncogenic mutations. Moshynska . . . [Full Text of this Article]


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Response to this Correspondence

RESPONSE: Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia
Oksana Moshynska and Anurag Saxena
J Natl Cancer Inst 2005 97: 1093-1095. [Extract] [Full Text] [PDF]