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JNCI Journal of the National Cancer Institute 2005 97(11):788-789; doi:10.1093/jnci/dji167
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© 2005 Oxford University Press

EDITORIAL

Cancer as a Risk Factor for Dementia: A House Built on Shifting Sand

Jeffrey S. Wefel, Christina A. Meyers

Affiliation of authors: Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston

Correspondence to: Jeffrey S. Wefel, PhD, Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 431, Houston, TX 77030 (e-mail: jwefel@mdanderson.org).

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As advances in therapy have improved the survival rates of patients diagnosed with cancer, various survivorship issues have received attention, including the incidence of cognitive dysfunction and its relative impact on patient quality of life. For example, patients with breast and prostate cancer have 5-year relative survival rates of approximately 86% and 98%, respectively (1). However, recent studies have demonstrated that cognitive dysfunction may be present before treatment, may worsen acutely secondary to treatment-related neurotoxicity, and may continue after cessation of therapy (2–5). Concerns that exposure to cancer and cancer treatments may augment a patient's chance of developing future neurologic diseases, including dementia, have also received recent attention. These concerns are amplified in an aging population that has an increased risk for both cancer and . . . [Full Text of this Article]


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 JNCI J Natl Cancer InstHome page
J. S. Wefel and C. A. Meyers
RESPONSE: Re: Cancer as a Risk Factor for Dementia: A House Built on Shifting Sand
J Natl Cancer Inst, October 19, 2005; 97(20): 1551 - 1552.
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 JNCI J Natl Cancer InstHome page
L. H. Heflin, B. E. Meyerowitz, P. Hall, P. Lichtenstein, B. Johansson, N. L. Pedersen, and M. Gatz
Re: Cancer as a Risk Factor for Dementia: A House Built on Shifting Sand
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