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JNCI Journal of the National Cancer Institute 2005 97(11):786-788; doi:10.1093/jnci/dji166
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© 2005 Oxford University Press

EDITORIAL

Palliative Single-Fraction Radiation Therapy: How Much More Evidence Is Needed?

Lisa Kachnic, Lawrence Berk

Affiliations of authors: Department of Radiation Oncology, Boston University Medical Center, Boston, MA (LK); Central Ohio Radiation Oncology, Columbus, OH (LB)

Correspondence to: Lisa Kachnic, MD, Department of Radiation Oncology, Boston University Medical Center, 88 East Newton St., EB 11, Boston, MA 02118 (e-mail: lisa.kachnic@bmc.org).

The first 150 words of the full text of this article appear below.

Bone metastases are a common manifestation of distant relapse from many types of solid malignancies, especially from cancers of the lung, breast, and prostate. Patients with a broad spectrum of solid cancers often develop painful bone metastases to the spine, pelvis, and extremities during the course of their disease (1). The goals of palliative treatment of bone metastases are pain relief, function preservation, and maintenance of skeletal integrity. Local-field external-beam radiation therapy is one well-recognized and effective palliative modality, with up to 80% of patients experiencing some improvement in their pain (2). Consensus statements from the National Comprehensive Cancer Network on Cancer Pain, the Second Workshop on Palliative Radiotherapy and Symptom Control, and the Ontario Guidelines for Palliative Pain advocate the use and efficacy of radiation therapy in palliating painful bone metastases (3–5).

There is continued debate over the . . . [Full Text of this Article]


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