© 2005 Oxford University Press
EDITORIAL |
A Crucial Role for Cellular Retinol-Binding Protein I in Retinoid Signaling
Correspondence to: Reuben Lotan, PhD, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX 77030 (e-mail: rlotan@mdanderson.org)
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Retinol (the prototypic vitamin A) and its metabolites called retinoids play important physiologic roles in embryonal development, vision, maintenance of epithelial differentiation, immune functions, and reproduction (1). Many of these functions are mediated by retinol metabolites such as all-trans-retinoic acid (ATRA) (2). ATRA modulates gene expression by means of nuclear receptors that are members of the steroid hormone gene superfamily. These receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs), appear in at least three subtypes, designated 
, 
, and 
. The receptors function as ligand-activated heterodimeric DNA-binding transcription enhancing factors and regulate the transcription of various
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