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JNCI Journal of the National Cancer Institute 2005 97(1):2-3; doi:10.1093/jnci/dji015
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© 2005 Oxford University Press

EDITORIAL

Lymphatic Regeneration: New Insights From VEGFR-3 Blockade

Yoshiyasu Aoki, Giovanna Tosato

Affiliation of authors: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Correspondence to: Giovanna Tosato, MD, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (e-mail: tosatog@mail.nih.gov)

The first 10% of the full text of this article appears below.

The lymphatic network is uniquely organized for the continuous removal of interstitial fluid and proteins, and for adsorption of dietary fat from the small intestine. Malfunction of the lymphatic system leads to lymphoedema (1). Lymphatic vessels are a conduit for lymphocytes and antigen-presenting cells, and importantly, for tumor cells that metastasize to distant sites through the lymphatic system. Recent progress in the field has come from the identification of molecules that characterize and regulate lymphatic vessel development and function (1,2). A critical advance came from the pioneering work by Alitalo and colleagues, who identified . . . [Full Text of this Article]


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