© 2005 Oxford University Press
IN THIS ISSUE |
In This Issue
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Antidepressant Use and Tamoxifen Metabolism
The efficacy of tamoxifen treatment for breast cancer varies widely among
women. The drug is metabolized by several cytochrome P450 (CYP) enzymes,
including the CYP2D6 isoform. Some selective serotonin reuptake inhibitors
(SSRIs), which are commonly prescribed to treat hot flashes in women who take
tamoxifen, are known to inhibit CYP2D6. Jin et al.
(p. 30) examined the
effects of concomitant SSRI use and CYP2D6 genotypes on plasma concentrations
of tamoxifen and its metabolites in women who were undergoing tamoxifen
therapy for breast cancer. After 4 months of tamoxifen therapy, women with a
CYP2D6 homozygous variant
CRBP-I Function in Breast Epithelium
VEGFR-3 and New Lymphatic Growth
Zinc Deficiency and Upper Aerodigestive Tract Cancer
Progesterone Receptor Gene and Ovarian Cancer Risk
Bone Turnover Markers and Skeletal Complications