© 2004 by Oxford University Press
© 2004 Oxford University Press
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Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer
Affiliations of authors: Breast and Gynaecological Cancer Laboratory (JP); Human Genetics Department (EH, AO, JB); Centro Nacional de Investigaciones Oncológicas, Madrid, Spain; Department of Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain (CR); Department of Genetics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (OD).
Correspondence to: José Palacios, MD, Breast and Gynaecological Cancer Laboratory, Molecular Pathology Programme, Centro Nacional Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro, 3, 28029 Madrid, Spain (e-mail: jpalacios@cnio.es)
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Several reports have established that sporadic breast carcinomas with expression of basal cell (myoepithelial cell) markers, such as P-cadherin and high molecular weight cytokeratins CK5/6, CK14, and CK17, show specific morphologic and prognostic characteristics (1,2). In cDNA studies, Perou et al. (3) also defined a subgroup of estrogen receptor (ER)-negative/HER2-negative breast cancers characterized by the expression of the basal cell markers. Recently, Sorlie et
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J Natl Cancer Inst 2004 96: 714.
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