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JNCI Journal of the National Cancer Institute 2004 96(9):645-647; doi:10.1093/jnci/djh147
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIALS

Science Peels the Onion of Selenium Effects on Prostate Carcinogenesis

Philip R. Taylor, Howard L. Parnes, Scott M. Lippman

Affiliations of authors: Cancer Prevention Studies Branch (PRT) and Division of Cancer Prevention (HLP), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Clinical Cancer Prevention, Division of Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX (SML).

Correspondence to: Scott M. Lippman, MD, Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 236, Houston, TX 77030 (e-mail: slippman@mdanderson.org)

The first 150 words of the full text of this article appear below.

The role of the essential trace element selenium in prostate cancer was first (and last) editorialized in the Journal in 1998 in conjunction with the report of the first large prospective observational study of selenium and the risk of advanced prostate cancer (1,2). Although the principals for the 1998 study were the same as those for the observational study by Li et al. (3) in this issue of the Journal, much has changed in the basic scientific understanding of selenium. The onion, an allium vegetable that concentrates selenium, is an apt metaphor for the scientific work of peeling back the layers of molecular effects and mechanisms underlying the strong selenium epidemiology in the prostate.

The past 6 years have seen the publication of seven prospective epidemiologic studies of selenium status and prostate cancer (including the study in this issue of the Journal) (2. . . [Full Text of this Article]


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Correspondence about this Article

Re: Science Peels the Onion of Selenium Effects on Prostate Carcinogenesis
Boguslaw Lipinski
J Natl Cancer Inst 2004 96: 1640. [Extract] [Full Text] [PDF]



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