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JNCI Journal of the National Cancer Institute 2004 96(8):581; doi:10.1093/jnci/96.8.581
© 2004 by Oxford University Press
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© 2004 Oxford University Press

NEWS

Unique Strategy Restores p53 Function in Mice

Mirella Bucci

The first 10% of the full text of this article appears below.

The tumor suppressor gene p53 can induce the tidy destruction of cells via the cellular suicide program called apoptosis. In more than half of all tumors, p53 is mutated or deleted. Malfunctions in ARF and MDM2, critical regulators of p53 function, occur in another 30% of tumors. With one notable exception, most of these mutations are sporadic (patients with Li–Fraumeni syndrome have an inherited p53 mutation). "p53 is the holy grail for cancer therapy," said Howard Hughes Medical Institute investigator Steve Dowdy, . . . [Full Text of this Article]

Fusion Protein

Other Attempts

Further Work


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