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© 2004 Oxford University Press
CORRESPONDENCE |
Re: Specific Antibody Levels at the Cervix During the Menstrual Cycle of Women Vaccinated With Human Papillomavirus 16 Virus-Like Particles
Affiliations of authors: Biologics Clinical Research, Merck Research Laboratories, West Point, PA (EB); HPV Research Group, Department of Epidemiology, University of Washington, Seattle (LAK).
Correspondence to: Eliav Barr, MD, Biologics Clinical Research, Merck Research Laboratories, West Point, PA 19486-0004 (e-mail: eliav_barr@ merck.com)
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We read with interest the article by Nardelli-Haefliger et al. (1) in which the authors reported an approximate ninefold reduction in cervical anti-human papillomavirus 16 (HPV16) immunoglobulin (Ig; specific IgG and total IgG and IgA) levels at the time of ovulation in 11 women who received aluminum-free (i.e., adjuvant-free) HPV16 L1 virus-like particle (VLP) vaccine synthesized in a baculovirus system (1). The authors hypothesized that the efficacy of prophylactic HPV16
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J Natl Cancer Inst 2004 96: 413-414.