Skip Navigation

JNCI Journal of the National Cancer Institute 2004 96(5):344-345; doi:10.1093/jnci/djh078
© 2004 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Griend, D. J. V.
Right arrow Articles by Rinker-Schaeffer, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griend, D. J. V.
Right arrow Articles by Rinker-Schaeffer, C. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2004 Oxford University Press

EDITORIAL

Suppression of Metastasis—A New Function for Known Proteins

Donald J. Vander Griend, Jonathan C. Berger, Carrie W. Rinker-Schaeffer

Affiliations of authors: Pritzker School of Medicine (JCB, CRS), Department of Surgery, Section of Urology, and Committee on Cancer Biology, Biological Sciences Division (DVG, CRS), The University of Chicago Cancer Research Center (CRS), The University of Chicago, Chicago, IL.

Correspondence to: Carrie Rinker-Schaeffer, PhD, Section of Urology, MC6038, The University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637 (e-mail: crinkers@midway.uchicago.edu)

The first 10% of the full text of this article appears below.

In this issue of the Journal, Chang et al. (1) report the identification of an unanticipated function for connective tissue growth factor (CTGF) in the regulation of aspects of lung cancer metastasis. Their data add to a growing body of literature identifying new functions of known proteins in the regulation of metastatic growth. The functional identification of metastasis suppressor proteins requires appropriately designed in vitro, in vivo, and clinical correlative studies to assess the role of the candidate protein in the metastatic process (2). To this end, the authors present three lines of evidence to support their assertion that CTGF functions as a metastasis suppressor in lung cancer. First, ectopic . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?