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JNCI Journal of the National Cancer Institute 2004 96(24):1808-1810; doi:10.1093/jnci/96.24.1808
© 2004 by Oxford University Press
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© 2004 Oxford University Press

NEWS

New Initiatives Aim To Test More Cancer Drugs for Children

Vicki Brower

The first 150 words of the full text of this article appear below.

Since the 1970s, the mortality rate for children and adolescents with cancer has dropped by almost 50%, but the cure rate for pediatric cancer has plateaued in the past several years because there are relatively few new drugs being tested for childhood cancers, says Joseph Simone, M.D., professor emeritus of medicine and pediatrics at the Huntsman Cancer Institute at the University of Utah in Salt Lake City.

The number of cancer cases in children and adolescents each year is small—about 12,500—compared with the number in adults, and drug companies are reluctant to invest money in clinical trials for such a small population. Moreover, it can be difficult to enroll enough patients who meet specific enrollment criteria. When drugs are tested, there is usually a 5- to 10-year gap between the time they reach adults and the time they reach children. "There is a consensus that there won't be a rise . . . [Full Text of this Article]

Targeted Therapy Focus

FDA Efforts

Preclinical Research


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Pediatric Research Equity Act
J Natl Cancer Inst 2004 96: 1810. [Extract] [Full Text] [PDF]