© 2004 by Oxford University Press
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© 2004 Oxford University Press
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Rexinoids May Be Ready for Prime Time in Prevention, But Challenges Remain
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Don't call rexinoids retinoids. Like a younger brother always standing in his big brother's shadow, rexinoids are frequently confused with their retinoid kin, the vitamin A derivatives that have been used in chemotherapy and to quell severe acne, among other things. Those who study rexinoids say few scientists are familiar with this class of compounds that deserves serious attention in chemotherapy and chemoprevention.
"Most people think of rexinoids as just another form of retinoids, but they most emphatically are not so," said Michael Sporn, M.D., of Dartmouth Medical School in Hanover, N.H., at a session he organized on rexinoids and their chemoprevention potential at the third annual American Association for Cancer Research Frontiers in Cancer Prevention Research conference held in October in Seattle.
Preclinical studies have shown that rexinoids, compounds that selectively
bind the multifunctional nuclear retinoid X
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