© 2004 by Oxford University Press
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© 2004 Oxford University Press
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Energy Boost: The Warburg Effect Returns in a New Theory of Cancer
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In 1930, German biochemist Otto Warburg, M.D., proposed that cancer was caused by altered metabolism—deranged energy processing—in the cell. Warburg, winner of a Nobel Prize in 1931, is now considered by many to be the greatest biochemist of the first half of the 20th century. His cancer theory, though, mostly fell on deaf ears. Altered metabolism "may be a symptom of [cancer], but not the primary cause," wrote fellow biochemist and Nobelist Hans Krebs, M.D., Ph.D., echoing the majority viewpoint. Warburg went to his grave in 1970 insisting he was right, but for 30 years his cancer theory appeared to be buried along with its originator.
Now Warburg's theory is enjoying a resurrection. Two prominent cancer
biologists contend that a shift in energy production from oxidative
phosphorylation to glycolysis—the so-called "Warburg
effect"—is a fundamental property of cancer cells, not just a
byproduct of the cell's transformation into cancer. "We think
Power Supply
Into the Clinic
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