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JNCI Journal of the National Cancer Institute 2004 96(22):1645-1647; doi:10.1093/jnci/djh332
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

Can Selenium Prevent Colorectal Cancer? A Signpost From Epidemiology

Anna J. Duffield-Lillico, Imad Shureiqi, Scott M. Lippman

Affiliations of authors: Epidemiology Service, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (AJDL); Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston (IS, SML)

Correspondence to: Scott M. Lippman, MD, Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 236, Houston, TX 77030 (e-mail: slippman@mdanderson.org)

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The limited epidemiology published heretofore on associations between selenium and colorectal adenomas or cancer has been mixed, inconclusive, and based predominantly on small studies. The epidemiology studies have been about evenly split between those showing a statistically significant (1–5) or suggestive (6,7) protective association and those showing a null (8–11) or suggestive harmful (12,13) association between selenium and colorectal adenomas or cancer. The strongest (and only clinical) previous support for a possible protective effect of selenium intake came from a large, randomized controlled trial of selenium in preventing nonmelanoma skin cancer (14). This trial showed a statistically significant reduction of colorectal cancer as a secondary endpoint (relative risk [RR] = 0.58, 95% confidence interval [CI] = 0.18 to 0.95) that attenuated after . . . [Full Text of this Article]


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