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JNCI Journal of the National Cancer Institute 2004 96(2):88-89; doi:10.1093/jnci/djh029
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

Postoperative Radiotherapy for Breast Cancer: Growing Evidence for an Impact on Survival

Katherine A. Vallis, Ian F. Tannock

Affiliations of authors: Departments of Radiation Oncology (KAV) and Medical Oncology and Hematology (IFT), Princess Margaret Hospital and University of Toronto, Toronto, Canada.

Correspondence to: Ian F. Tannock, MD, PhD, Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave., Toronto, Ontario M5G 2M9, Canada (e-mail: ian.tannock@uhn.on.ca)

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Postoperative radiotherapy for breast cancer is known to substantially reduce the risk of locoregional recurrence, both when given after mastectomy and after breast-conserving surgery. Recent reports [cited below] suggest that radiotherapy following mastectomy may also have a beneficial impact on survival, and the article by Vinh-Hung et al. (1), published in this issue of the Journal, further suggests that radiotherapy given after breast-conserving surgery improves survival.

Three randomized clinical trials (2–4) of postmastectomy radiotherapy, conducted in Canada and Denmark, have shown a 9%–10% improvement in overall survival at 10 years for patients that received radiotherapy compared with patients who did not receive radiotherapy. These results contrast with those of a patient-based meta-analysis of randomized clinical trials (5) in which radiotherapy was shown to be associated with a reduced risk of dying of breast cancer; however, this reduced . . . [Full Text of this Article]


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 JNCI J Natl Cancer InstHome page
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Postmastectomy Radiotherapy: Quality Counts!
J Natl Cancer Inst, January 4, 2006; 98(1): 3 - 4.
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 JNCI J Natl Cancer InstHome page
V. Vinh-Hung, C. Verschraegen, M. Royce, J. Van de Steene, P. Tai, G. Cserni, G. Storme, and G. Vlastos
RESPONSE: Re: Breast-Conserving Surgery With or Without Radiotherapy: Pooled-Analysis for Risks of Ipsilateral Breast Tumor Recurrence and Mortality
J Natl Cancer Inst, August 18, 2004; 96(16): 1255 - 1257.
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