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JNCI Journal of the National Cancer Institute 2004 96(18):1354-1355; doi:10.1093/jnci/96.18.1354
© 2004 by Oxford University Press
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© 2004 Oxford University Press

NEWS

For Phase I Studies, Ethical and Practical Concerns Abound

Kate Travis

The first 10% of the full text of this article appears below.

For researchers who conduct clinical trials, phase I studies are a hard sell: The drug or therapy is being tested in humans for the first time, the study has no hypothesis to test, and none of the accepted goals include a benefit to the patient. Instead, patients are asked to be willing participants in research that may—or may not—help cancer patients in the future.

"The history of human experimentation can be traced back as long as the history of medicine," said Neil Abramson, M.D., of the Baptist Cancer Institute in Jacksonville, Fla., who chaired a symposium on the practical and ethical issues of phase I research at this year's annual meeting of the American Society of Clinical Oncology (ASCO). "When is it right to experiment . . . [Full Text of this Article]


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