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JNCI Journal of the National Cancer Institute 2004 96(17):1270-1271; doi:10.1093/jnci/96.17.1270
© 2004 by Oxford University Press
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© 2004 Oxford University Press

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Three Molecularly Targeted Drugs Tested in Kidney Cancer Clinical Trials

Rabiya S. Tuma

The first 10% of the full text of this article appears below.

Kidney cancer is difficult to treat; for most patients, only surgery offers the prospect of curing the disease, and chemotherapy and radiation offer only palliative benefit. But early results from three phase I/II studies of three molecularly targeted drugs presented at this year's annual meeting of the American Society of Clinical Oncology (ASCO) suggest that targeting the underlying biology of these tumors is worthy of further study.

Clear-cell renal cancer is the most common form of kidney cancer, and the tumors in 90% of these patients have lost the Von Hippel-Lindau (VHL) tumor suppressor gene. Loss of this activity stimulates expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF)—both of which are . . . [Full Text of this Article]


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Related Stat Bite

Stat Bite: Incidence of and Mortality From Kidney Cancer, 1975-2001
J Natl Cancer Inst 2004 96: 1271. [Extract] [Full Text] [PDF]