© 2004 by Oxford University Press
© 2004 Oxford University Press
IN THIS ISSUE |
In This Issue
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Ceramide Pathway of Apoptosis in Neuroblastoma
The lipid second messenger ceramide, which is generated by both acidic and
neutral sphingomyelinases or by ceramide synthases, is a common intermediate
of many apoptotic pathways. Metabolism of ceramide involves several enzymes,
including glucosylceramide synthase and GD3 synthase, and results in the
formation of gangliosides (GM3, GD3, and GT3), which in turn promote the
generation of reactive oxygen species (ROS) and apoptosis. Lovat et al.
(p. 1288) explored how
fenretinide, a retinoic acid derivative, induces apoptosis via increases in
ceramide levels in neuroblastoma cells. The authors identified a novel pathway
of fenretinide-induced ROS generation and
Blocking Tumor Response to Glucose Deprivation
Probabilities of Death From Breast Cancer and Other Causes
Burden of Illness in Cancer Survivors
Interferon Alfa Immunotherapy and STAT1 Activation
Diet and Exercise Patterns and Cancer and Disease Prevention