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JNCI Journal of the National Cancer Institute 2004 96(16):1194-1195; doi:10.1093/jnci/djh256
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

Involvement of Heparanase in Tumor Metastases: A New Target in Cancer Therapy?

Douglas D. Boyd, Motowo Nakajima

Affiliation of authors: Department of Cancer Biology, M. D. Anderson Cancer Center, Houston, TX (DDB); Novartis, Tsukuba, Japan (MN)

Correspondence to: Douglas D. Boyd, PhD, Department of Cancer Biology, Box 173, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: dboyd@mdanderson.org)

The first 10% of the full text of this article appears below.

Ultimately, the cause of death for many cancer patients is the presence of metastases, the spread of the cancer from primary to distant sites. One of the critical steps in metastasis is the ability of tumor cells to degrade basement membrane structures that underlie the epithelial and endothelial cell layers, and much research has focused on the identification of genes that contribute to this process. Consequently, several distinct classes of proteases, including collagenases, cathepsins, serine proteases, and endoglycosidases, contribute to the dissolution of the basement membrane. Heparanase, the predominant enzyme in the endoglycosidase class, degrades heparan sulfate glycosaminoglycan—the principal polysaccharide . . . [Full Text of this Article]


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