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JNCI Journal of the National Cancer Institute 2004 96(16):1191; doi:10.1093/jnci/96.16.1191
© 2004 by Oxford University Press
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© 2004 Oxford University Press

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Potential Selection Bias in Intervention Studies

Studies that evaluate the effects of proposed interventions to reduce the risk of disease among carriers of a highly penetrant mutation are important. In a commentary, Wacholder (p. 1204) argues that some of these studies may be susceptible to a serious selection bias when they are based in clinics that care for people at high risk for the disease. He explains how a study design in which a large fraction of the case patients were diagnosed before being seen at the clinic and in which all control subjects . . . [Full Text of this Article]

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