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JNCI Journal of the National Cancer Institute 2004 96(15):1184-1185; doi:10.1093/jnci/djh236
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CORRESPONDENCE

Re: BRCA1 and BRCA2 Founder Mutations and the Risk of Colorectal Cancer

Bernard Friedenson

Correspondence to: Bernard Friedenson, PhD, Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois—Chicago, 900 S. Ashland Ave., Chicago, IL 60607 (e-mail: molmeddoc@yahoo.com)

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Recently, excellent studies (1,2) concluded that Ashkenazi founder mutations in BRCA1 and/or BRCA2 (BRCA1/2) are not associated with a clinically meaningful increased risk of colorectal cancer. However, the possibility remains that once transformation begins in mutation carriers, colorectal cancer will progress more rapidly so that it can be detected at a younger age. Point estimates (1) suggest that BRCA1/2 founder mutation carriers might be at increased risk for earlier colorectal cancer (for those <65 years old, odds . . . [Full Text of this Article]


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Response to this Correspondence

RESPONSE: Re: BRCA1 and BRCA2 Founder Mutations and the Risk of Colorectal Cancer
Bethany L. Niell, Gad Rennert, Joseph D. Bonner, and Stephen B. Gruber
J Natl Cancer Inst 2004 96: 1185-1186. [Extract] [Full Text] [PDF]



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