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JNCI Journal of the National Cancer Institute 2004 96(13):982-983; doi:10.1093/jnci/96.13.982
© 2004 by Oxford University Press
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© 2004 Oxford University Press

NEWS

Running Interference: Pace Picks Up on Synthetic Lethality Research

Ken Garber

The first 150 words of the full text of this article appear below.

Visionary ideas sometimes languish for years. Back in 1995, cell biologist Lee Hartwell, Ph.D., and pediatric oncologist Stephen Friend, M.D., Ph.D., backed by the National Cancer Institute, launched the Seattle Project. The goal: identify novel anticancer drug targets by performing full-genome genetic screens in mutant strains of yeast. However, Hartwell soon departed to take charge of the Fred Hutchinson Cancer Research Center, and Friend left to join the biotechnology company Rosetta Inpharmatics. (Hartwell won the 2001 Nobel Prize for Physiology or Medicine for his work on the cell cycle.) The Seattle Project lost momentum and did not achieve its goals. But one of its main concepts lay dormant, waiting for technology to catch up.

That moment has now arrived. The new technology is RNA interference (RNAi), unknown back in 1997. Thanks to RNAi, Hartwell and Friend's idea, synthetic lethality, is now enjoying a resurrection. It is being used not only . . . [Full Text of this Article]

TRAIL of Death

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