© 2004 by Oxford University Press
© 2004 Oxford University Press
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Calcium Supplementation and Large Bowel Polyp Risk
Data from clinical trials indicate that calcium supplements modestly
decrease the risk of colorectal adenomas, but calcium's effect on different
types of colorectal lesions is unclear. Wallace et al.
(p. 921) compared the
occurrence of different types of colorectal lesions in 930 patients who were
randomly assigned to take either calcium carbonate supplements or a placebo
after a previous diagnosis of colorectal adenomas. Although the data suggested
that taking supplemental calcium is associated with a lower risk of developing
advanced lesions compared with taking placebo, the study found weaker
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