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JNCI Journal of the National Cancer Institute 2004 96(10):727-729; doi:10.1093/jnci/djh154
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

Mature Results of Adjuvant Colon Cancer Trials From the Fluorouracil-Only Era

Jean L. Grem

Affiliation of author: Department of Internal Medicine, Section of Oncology/Hematology, and the Eppley Cancer Center, University of Nebraska Medical Center, Omaha.

Correspondence to: Jean L. Grem, MD, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198-7680 (e-mail: jgrem@unmc.edu)

The first 10% of the full text of this article appears below.

In this issue of the Journal, Labianca et al. (1) report the results of a randomized trial comparing intraportal chemotherapy, systemic chemotherapy, or the combination of both regimens as adjuvant therapy for patients with Dukes’ stage B or C colon carcinoma. 5-Fluorouracil at a dosage of 500 mg/m2 of body surface area with 5000 IU of heparin was given through the portal vein for 7 days, starting on the day of surgery (IP regimen). Systemic therapy involved intravenous administration of leucovorin at 100 mg/m2 over a 2-hour period followed by bolus 5-fluorouracil at 370 mg/m2 daily on days 1–5, repeated every 28 days for six cycles (SY regimen). Over 6 years, 1199 patients were randomly assigned to treatment during surgery, and 1084 patients deemed eligible were analyzed. A higher percentage . . . [Full Text of this Article]


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