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JNCI Journal of the National Cancer Institute 2004 96(10):725-727; doi:10.1093/jnci/djh156
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

HERe-2 Stay: The Continuing Importance of Translational Research in Breast Cancer

George W. Sledge, Jr.

Correspondence to: George W. Sledge, Jr., MD, Indiana Cancer Pavilion, Indiana University School of Medicine, RT-473, 535 Barnhill Dr., Indianapolis, IN 46202 (e-mail: gsledge@iupui.edu)

The first 150 words of the full text of this article appear below.

This issue of the Journal contains two important articles that discuss human epidermal growth factor receptor 2 (HER2), also known as c-erbB2 or neu, as a therapeutic target in breast cancer (1,2). The first details preclinical studies that examine the combination of trastuzumab with a number of chemotherapeutic agents. The second applies the knowledge learned in the preclinical studies to the clinical setting and the treatment of patients with HER2-positive metastatic breast cancer. These studies are important with regard to what they tell us about HER2-positive breast cancer and its treatment and about a style of research. All have important implications.

HER2 is a member of a family of transmembrane receptor tyrosine kinases. To summarize more than two decades of research, HER2 lacks a functioning ligand-binding domain yet represents the preferred dimerization partner for other members of the EGFR family (3,4). Since . . . [Full Text of this Article]


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