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JNCI Journal of the National Cancer Institute 2004 96(1):4-5; doi:10.1093/jnci/djh027
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

What Now for Aspirin and Cancer Prevention?

John A. Baron

Correspondence to: John A. Baron, MD, MS, MSc, Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756 (e-mail: john.a.baron@dartmouth.edu)

The first 10% of the full text of this article appears below.

Could it really be that aspirin increases the risk of pancreatic cancer, as suggested in the article by Schernhammer et al. (1)? In many ways, aspirin has been a wonder child of chronic disease prevention. The drug is very effective in the secondary (chemo)prevention of cardiovascular disease and may also have a role in primary cardiovascular prevention (2). For neoplasia, clinical trials have recently established that aspirin can reduce the risk of sporadic colorectal adenomas (3–5), just as other nonsteroidal anti-inflammatory drugs (NSAIDs) cause regression of adenomas in familial adenomatous polyposis (6,7). Epidemiologic data also . . . [Full Text of this Article]


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