© 2003 by Oxford University Press
Journal of the National Cancer Institute, Vol. 95, No. 7, E3,
April 2, 2003
© 2003 Oxford University Press
ONLINE PERSPECTIVE |
Bacterial Infections as a Cause of Cancer
Correspondence to: Pelayo Correa, M.D., Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112-1393 (e-mail: correa@lsuhsc.edu).
| The first 150 words of the full text of this article appear below. |
Journal of the National Cancer Institute, Vol. 95, No. 6, © Oxford University Press 2003, all rights reserved.
HISTORICAL PERSPECTIVES
Cancer research in the 20th century thoroughly documented the role of major carcinogenic agents: ionizing radiation, chemical carcinogens, viruses, and especially tobacco smoke. Abundant epidemiologic studies have confirmed their role as causes of human cancer. Preventive strategies have been designed and applied with reasonably good results. Some exposures have proven difficult to avoid, especially tobacco smoking, where psychological mechanisms leading to addiction have proven cryptic and difficult to control.
The new century brings a new challenge: defining the impact of bacterial infections as a cause of cancer and design strategies for their prevention and control. Chronic inflammation has long been suspected of playing a role in carcinogenesis, but the mechanisms by which inflammation causes cancer remain poorly understood.
RECENT SCIENTIFIC CONTRIBUTIONS
Recently, infection with Helicobacter pylori has been classified as a human carcinogen by
DETERMINANTS OF CANCER RISK
CANCER PREVENTION
EPILOGUE
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