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JNCI Journal of the National Cancer Institute 2003 95(6):422-423; doi:10.1093/jnci/95.6.422
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 6, 422-423, March 19, 2003
© 2003 Oxford University Press

NEWS

Validating Biomarkers: Early Detection Research Network Launches First Phase III Study

Tom Reynolds

The first 150 words of the full text of this article appear below.

The National Cancer Institute’s Early Detection Research Network (EDRN) will launch its first phase III study of a biomarker in the next few months. Designed to evaluate microsatellite instability as a marker for recurrent bladder cancer, the multicenter collaboration is expected to become the first of many that will emerge in the coming years from the network’s wide-ranging consortium of biomarker discovery and validation laboratories.

The EDRN, established 3 years ago, aims to exploit the powerful new tools of biotechnology to rapidly bring molecular markers to the clinic (see News, May 17, 2000). In contrast to clinical testing of new therapeutic agents, which has a well-defined development sequence, biomarker development lacked an agreed-upon structure to bring a marker from discovery to clinical application—until the establishment of the EDRN.

In 2001, the EDRN unveiled a "road map" outlining five phases of biomarker development (see News, July 18, 2001), which . . . [Full Text of this Article]

Microsatellite Instability

Genomics

Epigenomics

Proteomics


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