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JNCI Journal of the National Cancer Institute 2003 95(6):420-421; doi:10.1093/jnci/95.6.420
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 6, 420-421, March 19, 2003
© 2003 Oxford University Press

EDITORIAL

Interferon-{alpha} Is Implicated in the Transcriptional Regulation of Vascular Endothelial Growth Factor

Giovanna Tosato

Correspondence to: Giovanna Tosato, M.D., Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892 (e-mail: tosatog@mail.nih.gov).

The first 10% of the full text of this article appears below.

A number of seminal observations over the last century have linked tumor growth with increased vascularization. In 1945, Algire et al. (1) noted that transplanted tumor cells could induce vessel sprouting before substantial tumor growth occurred and suggested that tumor explants require the development of a new vascular supply to grow. He further proposed that ". . . it is entirely possible that the change in the tumor cell that enables it to evoke capillary proliferation is the only change necessary to give the tumor cell its increased autonomy of growth relative to the normal cell from which it arose." In the 1960s, Ian Tannock (2) observed that . . . [Full Text of this Article]


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