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JNCI Journal of the National Cancer Institute 2003 95(5):350-351; doi:10.1093/jnci/95.5.350
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 5, 350-351, March 5, 2003
© 2003 Oxford University Press

NEWS

Microarray Studies Challenge Theories of Metastasis

Tracy Webb

The first 10% of the full text of this article appears below.

The common assumption about metastasis is that a primary tumor starts off benign and over time acquires mutations that provide a few rare cells within the tumor the ability to metastasize. This process, known as multistep tumorigenesis, is the basis for stressing the value of early detection because it is believed that if a tumor is detected and treated before it spreads, then the chances of survival are increased.

However, two new studies used microarrays to challenge that assumption and suggest that acquisition of the metastatic phenotype may not necessarily occur late in development for all tumors. Some tumors may actually start out deadly to begin with.

The first study, led by René Bernards, Ph.D., professor of molecular carcinogenesis at The Netherlands Cancer . . . [Full Text of this Article]

Clinical Significance

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