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JNCI Journal of the National Cancer Institute 2003 95(3):180-181; doi:10.1093/jnci/95.3.180
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 3, 180-181, February 5, 2003
© 2003 Oxford University Press

EDITORIAL

Familial Pancreatic Cancer: Where Are We in 2003?

Gloria M. Petersen, Ralph H. Hruban

Affiliations of authors: G. M. Petersen, Mayo Clinic, Rochester, MN; R. H. Hruban, Johns Hopkins Medical Institutions, Baltimore, MD.

Correspondence to: Gloria M. Petersen, Ph.D., Dept. of Health Sciences Research, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (e-mail: peterg@mayo.edu).

The first 10% of the full text of this article appears below.

There is a sense of déjà vu for those of us involved in pancreatic cancer research. Many of us have had the opportunity to witness the buildup leading to spectacular discoveries of major genes in studies of hereditary colorectal cancer and breast cancer families. In the same way, we are tackling pancreatic cancer through the use of high-risk pedigrees, a task that is much more difficult with a malignancy that is no more than one-fifth as common as and much more deadly than breast or colorectal cancers (1). Our experiences also parallel those of researchers who are searching for a major hereditary prostate cancer gene but are instead finding that multiple genes, each of modest effect, may tell the story of that disease. In the case of familial pancreatic cancer (FPC), we have not yet identified hypothesized novel . . . [Full Text of this Article]


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