© 2003 by Oxford University Press
© 2003 Oxford University Press
EDITORIAL |
A New Link Between Fanconi Anemia and Human Papillomavirus–Associated Malignancies
Affiliations of authors: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD (DRL); The Johns Hopkins Medical Institutions, The Johns Hopkins University, Baltimore, MD (MLG).
Correspondence to: Douglas R. Lowy, MD, Laboratory of Cellular Oncology, Bldg. 37, Rm. 4106, MSC 4263, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (e-mail: drl@helix.nih.gov)
| The first 150 words of the full text of this article appear below. |
In this issue of the Journal, Kutler et al. (1) provide evidence that Fanconi anemia patients have an inherited susceptibility to human papillomavirus (HPV)-associated malignancies. Fanconi anemia is a group of rare autosomal recessive conditions characterized by congenital abnormalities, progressive bone marrow failure, and a predisposition to both acute myelogenous leukemia and certain solid tumors. Systematic reviews of the Fanconi anemia literature, surveys of Fanconi anemia patients, and data from the International Fanconi Anemia Registry (IFAR) have identified an unusual preponderance of head and neck squamous cell carcinomas and anogenital tract malignancies among Fanconi anemia patients (2–5). For example, among 754 patients enrolled in the IFAR, 28% developed solid tumors by the age of 40 years (5). The risk of head and neck squamous cell carcinomas among Fanconi anemia patients enrolled in the IFAR is approximately 500-fold higher than it
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Rani, J. Li, and Q. Pang Differential p53 Engagement in Response to Oxidative and Oncogenic Stresses in Fanconi Anemia Mice Cancer Res., December 1, 2008; 68(23): 9693 - 9702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Spardy, A. Duensing, D. Charles, N. Haines, T. Nakahara, P. F. Lambert, and S. Duensing The Human Papillomavirus Type 16 E7 Oncoprotein Activates the Fanconi Anemia (FA) Pathway and Causes Accelerated Chromosomal Instability in FA Cells J. Virol., December 1, 2007; 81(23): 13265 - 13270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fakhry and M. L. Gillison Clinical Implications of Human Papillomavirus in Head and Neck Cancers J. Clin. Oncol., June 10, 2006; 24(17): 2606 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Alter, H. Joenje, A. B. Oostra, and G. Pals Fanconi Anemia: Adult Head and Neck Cancer and Hematopoietic Mosaicism Arch Otolaryngol Head Neck Surg, July 1, 2005; 131(7): 635 - 639. [Full Text] [PDF]
|
|
|
|
|
|
S. Houghtaling, L. Granville, Y. Akkari, Y. Torimaru, S. Olson, M. Finegold, and M. Grompe Heterozygosity for p53 (Trp53+/-) Accelerates Epithelial Tumor Formation in Fanconi Anemia Complementation Group D2 (Fancd2) Knockout Mice Cancer Res., January 1, 2005; 65(1): 85 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Smith, T. H. Haugen, and L. P. Turek RESPONSE: Re: Human Papillomavirus in Oral Exfoliated Cells and Risk of Head and Neck Cancer J Natl Cancer Inst, August 4, 2004; 96(15): 1182 - 1183. [Full Text] [PDF]
|
|