© 2003 by Oxford University Press
© 2003 Oxford University Press
EDITORIAL |
Thymosin 
4: A New Molecular Target for Antitumor Strategies
Correspondence to: Allan L. Goldstein, PhD, Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I St., NW, Rm. 530, Washington, DC 20037 (e-mail: bcmalg@gwumc.edu)
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Until recently, little attention has been paid to the nuclear activities of actin, a housekeeping protein, or the actin-sequestering molecule thymosin 
4, or to their use as potential targets for antitumor strategies. This lack of attention has been due, in part, to the fact that these molecules are associated primarily with the structural activities of the cytoskeleton and with basic physiologic functions associated with differentiation, adhesion, wound healing, and cell motility. It now appears that actin and some of the molecules that regulate actin are bona fide residents of the nucleus and may play previously unrecognized roles in tumor metastasis and angiogenesis (1).
The findings reported by Cha et al. (2) in this issue of the Journal demonstrate important new activities for thymosin 4, a molecule found in
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