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JNCI Journal of the National Cancer Institute 2003 95(2):98-100; doi:10.1093/jnci/95.2.98
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 2, 98-100, January 15, 2003
© 2003 Oxford University Press

NEWS

Selenium for Prevention: Eating Your Way to Better DNA Repair?

Robert Longtin

The first 150 words of the full text of this article appear below.

For researchers who study the cancer-inhibiting mechanisms of selenium, the scientific literature generally comes in two flavors. Selenium is seen as either a beneficial scavenger of DNA-damaging oxygen free radicals or as a potent inducer of apoptosis that eliminates damaged, potentially cancerous cells.

Now a third flavor could be on the menu. Scientists at Indiana University in Indianapolis reported recently in the Proceedings of the National Academy of Sciences that high levels of selenomethionine, the primary organic form of selenium, prompts cells in culture to initiate DNA repair, a key mechanism in preventing cancer. The group, led by Martin Smith, Ph.D., shows that the nutrient indirectly switches on a DNA repair subpathway controlled by the regulatory protein p53.

The finding raises the intriguing, but still scientifically murky, possibility that people with functional p53 could boost their capacity for DNA repair by simply increasing their dietary intake of selenomethionine by, for . . . [Full Text of this Article]

Common Trace Element

New Awareness

Enter DNA Repair

How Much Is Enough?

Miles Away


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