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JNCI Journal of the National Cancer Institute 2003 95(2):100-102; doi:10.1093/jnci/95.2.100
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 2, 100-102, January 15, 2003
© 2003 Oxford University Press

NEWS

Estrogen and DNA Damage: The Silent Source of Breast Cancer?

Katharine Miller

The first 10% of the full text of this article appears below.

In December, the hormone estrogen was declared a known human carcinogen by the National Toxicology Program. The association between estrogen and cancer is nothing new; the relationship between estrogen-driven cell proliferation and uterine cancer is well known, and women with higher lifelong exposure to estrogen (resulting from early menses and late menarche) have an elevated risk of breast cancer. But now that estrogen appears in the Tenth Report on Carcinogens, the question has turned from whether estrogen causes cancer to how it causes cells to become malignant.

One group of scientists thinks that there is more to estrogen’s cancer-causing properties than most researchers believe. This rebellious group has long seen estrogen metabolites as cancer initiators. . . . [Full Text of this Article]


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