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JNCI Journal of the National Cancer Institute 2003 95(17):1273-1274; doi:10.1093/jnci/95.17.1273
© 2003 by Oxford University Press
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© 2003 Oxford University Press

NEWS

Clinical Trials Test Bisphosphonates in Hormone-Sensitive Prostate Cancer

Charles Bankhead

The first 10% of the full text of this article appears below.

Buoyed by results in patients with hormone-refractory prostate cancer, investigators have begun to push the therapeutic envelope of using bisphosphonates to prevent bone loss and bone-related complications in patients with hormone-sensitive metastatic disease.

Last year results of a randomized, multicenter clinical trial demonstrated that treatment with the bisphosphonate zoledronic acid reduced the rate of skeletal-related events (SREs) in patients with hormone-refractory prostate cancer. Follow-up reports at this year’s American Urological Association (AUA) meeting showed that zoledronic acid delayed the occurrence of a first SRE by more than 5 months and that the benefits initially observed were maintained for 24 months.

Although encouraging, the findings only apply to a minority . . . [Full Text of this Article]

Stopping Bone Degredation

Use in Earlier Stages

Promising Results


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